JmjC domain-containing histone demethylation protein 2C; Jumonji domain-containing protein 1C; thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8 (JMJD1C, JHDM2C, KIAA1380, TRIP8)

Function

• probable histone demethylase that specifically demethylates Lys-9 of histone H3, thus playing a role in histone code
• demethylation of Lys generates formaldehyde & succinate
• may be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts specifically with the ligand-binding domain of the thyroid hormone receptor; requires presence of thyroid hormone for its interaction

Cofactor:

• binds 1 Fe+2 ion per subunit (putative)

Structure

• Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate association with nuclear receptors (putative)
• belongs to the JHDM2 histone demethylase family
• contains 1 JmjC domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Pathology

• JMJD1C gene variants associated positively endogenous serum testosterone & with thromboembolism (odds ratio, 2.1) & heart failure (OR, 7.8) in men
  • associateions not as marked in women

More general terms

• thyroid hormone receptor interacting protein (TRIP)
• zinc finger protein
• phosphoprotein
• histone demethylase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=221037
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:221037
• OMIM: https://mirror.omim.org/entry/604503
• UniProt: http://www.uniprot.org/uniprot/Q15652.html