high mobility group nucleosome-binding domain-containing protein 3; thyroid receptor-interacting protein 7; TR-interacting protein 7; TRIP-7 (HMGN3, TRIP7, PNAS-24)

Function

• binds to nucleosomes, regulating chromatin structure & consequently, chromatin-dependent processes including transcription, DNA replication & DNA repair
• affects both insulin & glucagon levels & modulates expression of pancreatic genes involved in insulin secretion
• regulates expression of the glucose transporter SLC2A2 by binding specifically to its promoter region & recruiting PDX1 & additional transcription factors
• regulates expression of SLC6A9, a glycine transporter that regulates glycine concentration in synaptic junctions in the CNS, by binding to its transcription start site
• may play a role in ocular development & astrocyte function
• interacts with the ligand binding domain of the thyroid hormone receptor (in vitro); requires the presence of thyroid hormone for its interaction
• interacts with nucleosomes

Structure

belongs to the HMGN family

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate & uterus
• low expression in liver, spleen, placenta & ovaries
• induced by estrogen

More general terms

• thyroid hormone receptor interacting protein (TRIP)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9324
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9324
• OMIM: https://mirror.omim.org/entry/604502
• UniProt: http://www.uniprot.org/uniprot/Q15651.html