solute carrier family 2 member 2; glucose transporter type 2, liver; GLUT-2 (SLC2A2, GLUT2)

Function

• facilitative glucose transporter
• facilitates glucose uptake at glucose concentrations above normal fasting range (3-6 mM)
• likely mediates bidirectional transfer of glucose across the plasma membrane of hepatocytes
• responsible for uptake of glucose by the beta cells of the islets of Langerhans
• may comprise part of the glucose-sensing mechanism of the beta cell
• may also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine & kidney
• required for stability & retention at the cell surface of pancreatic beta cells (putative)

Structure

• N-glycosylated
• belongs to the major facilitator superfamily, sugar transporter (TC 2.A.1.1) family, glucose transporter subfamily

Compartment

membrane

Expression

• expressed in liver, insulin-producing beta cell of pancreatic islets, small intestine & kidney

Pathology

• defects in SLC2A2 are the cause of Fanconi-Bickel syndrome

More general terms

• glucose transporter
• solute carrier family 2 (SLC2, SLC2A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6514
• OMIM: https://mirror.omim.org/entry/138160
• OMIM: https://mirror.omim.org/entry/227810
• UniProt: http://www.uniprot.org/uniprot/P11168.html