Na+/glucose cotransporter
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Function
- Na+ is co-tranported with glucose
- the Na+ gradient provides the driving force for the transport
- efficient substrate transport in mammalian kidney is provided by a low affinity high capacity & a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules
Structure
- binding sites for glucose & Na+
More general terms
More specific terms
- Na+/glucose cotransporter 1 (high affinity Na+-glucose cotransporter, solute carrier family 5 member1, SLC5A, NAGT, SGLT1)
- Na+/glucose cotransporter 3 (low affinity Na+-glucose cotransporter, solute carrier family 5 member 4, SLC5A4, SAAT1, SGLT3)
- Na+/glucose cotransporter 5 (Na+/glucose cotransporter 5, solute carrier family 5 member 10, SLC5A10, SGLT5)
References
- ↑ Unger RH Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells. Science 251:1200 1991 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2006409
- ↑ Textbook of Medical Physiology, 8th ed., AC Guyton, WB Saunders, Philadelphia, 1991, pg 48
- ↑ UniProt http://www.uniprot.org/uniprot/P13866.html