Na+/Cl- dependent glycine transporter 1; GlyT1; solute carrier family 6 member 9 (SLC6A9)

Function

• terminates action of glycine by high affinity Na+ dependent reuptake of glycine into presynaptic terminals
• may play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission

Structure

• belongs to the Na+:neurotransmitter symporter (SNF) family

Compartment

membrane

Alternative splicing

named isoforms=3, GlyT-1A, 1B, 1C

Expression

• all GLYT-1 subtypes can be found in brain, kidney, pancreas, lung, placenta, liver
• GLYT-1C subtype is only found in the brain

More general terms

• solute carrier family 6
• amino acid transport protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6536
• OMIM: https://mirror.omim.org/entry/601019
• UniProt: http://www.uniprot.org/uniprot/P48067.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6536