dual specificity protein phosphatase 26 (low-molecular-mass dual-specificity phosphatase 4, LDP-4, DSP-4, mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, novel amplified gene in thyroid anaplastic cancer, dual specificity phosphatase SKRP3, DUSP26, DUSP24, LDP4, MKP8, NATA1, SKRP3)

Function

• inactivates MAPK1 & MAPK3 which leads to dephosphorylation of heat shock factor protein 4 & diminishes its DNA-binding activity
• inhibits MAP kinase p38 by dephosphorylating it
• induces activation of MAP kinase p38 & c-Jun N-terminal kinase (JNK)
• interacts with HSF4

Structure

• belongs to the protein-tyrosine phosphatase family, non-receptor class dual specificity subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

cytoplasm, nucleus, Golgi

Alternative splicing

named isoforms=2

Expression

• brain
• in the brain, expressed ubiquitously except in hippocampus

Pathology

• expressed in embryonal cancers (retinoblastoma, neuroepithelioma & neuroblastoma) & in anaplatic thyroid cancer
• inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells

More general terms

• dual specificity phosphatase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BV47.html