Toll-like receptor 8; CD288 (TLR8)

Function

• innate immune response to microbial agents
• acts via MyD88 & TRAF6
  • NF-kappa-B activation
  • cytokine secretion
  • inflammatory response
• binds MyD88 via their respective TIR domains

Structure

• belongs to the Toll-like receptor family
• contains 24 LRR repeats (leucine-rich repeats)
• contains 1 TIR domain

Compartment

membrane

Expression

• expressed in brain, heart, lung, liver, placenta
• expressed in monocytes > in CD11c+ immature dendritic cells

More general terms

• toll-like receptor
• leucine-rich repeat-containing protein (LRRC)
• glycoprotein
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5131
• OMIM: https://mirror.omim.org/entry/300366
• UniProt: http://www.uniprot.org/uniprot/Q9NR97.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51311