Toll-like receptor 7 (TLR7)

Function

• innate immune response to microbial agents
• acts via MyD88 & TRAF6
  • NF-kappa-B activation
  • cytokine secretion
  • inflammatory response
• binds MyD88 via their respective TIR domains

Structure

• belongs to the Toll-like receptor family
• contains 27 LRR repeats (leucine-rich repeats)
• contains 1 TIR domain

Compartment

membrane

Expression

• expressed in brain, placenta, spleen, stomach, small intestine, lung, in plasmacytoid pre-dendritic cells

Pathology

• gain of function in TLR7 implicated in systemic lupus erythematosus

Genetics

• X-chromosome linked

More general terms

• toll-like receptor
• phosphoprotein
• leucine-rich repeat-containing protein (LRRC)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5128
• OMIM: https://mirror.omim.org/entry/300365
• UniProt: http://www.uniprot.org/uniprot/Q9NYK1.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51284