calcitonin gene-related peptide [CGRP] receptor (CALCRL, CGRPR)
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Function
- guanine nucleotide exchange factor & cell surface receptor.
- in association with RAMP1, forms receptor for calcitonin-gene-related peptide (CGRP)
- in association with RAMP2 or RAMP3 forms receptor for adrenomedullin
- activity mediated by G proteins which activate adenylyl cyclase
- heterodimer of CALCRL & RAMP1, RAMP2 or RAMP3
Structure
belongs to the G-protein coupled receptor 2 family
Compartment
Expression
predominantly expressed in the lung & heart
More general terms
Additional terms
- calcitonin gene-related peptide (CGRP)
- calcitonin gene-related peptide-receptor component protein (CGRP-receptor component protein, CGRP-RCP, CGRPRCP, CRCP)
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q16602.html
- ↑ Miles K, Greengard P, Huganir RL. Calcitonin gene-related peptide regulates phosphorylation of the nicotinic acetylcholine receptor in rat myotubes. Neuron. 1989 May;2(5):1517-24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2560647