paired-like homeobox protein PEPP-1; ovary-, testis- & epididymis-expressed gene protein (PEPP1, OTEX, RHOXF1)
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Function
- transcription factor involved in reproductive processes
- does not interact with itself
- not expressed in placenta
Structure
- belongs to the paired-like homeobox family, PEPP subfamily
- contains 1 homeobox DNA-binding domain
Compartment
Expression
- expressed in ovary, testis, epididymis
- expressed in prostate & mammary gland
- not expressed in placenta
- induced by androgens
- not expressed in placenta
Pathology
- expressed in many tumor cell lines derived from acute lymphocytic leukemia, prostate cancer, endometrial adenocarcinoma, melanoma, bladder carcinoma, colon carcinoma, erythroleukemia & breast carcinoma