homeobox protein BarH-like 2 (BARX2)

Function

• transcription factor
• binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'
• may control expression of neural adhesion molecules such as CD171 during embryonic development of both the CNS & PNS
• may be involved in controlling adhesive processes in keratinizing epithelia (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the BAR homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Expression

• highly expressed in adult salivary gland
• expressed at much lower levels in mammary gland, kidney & placenta

More general terms

• homeobox protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8538
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8538
• OMIM: https://mirror.omim.org/entry/604823
• UniProt: http://www.uniprot.org/uniprot/Q9UMQ3.html