homeobox protein PBX2; pre B-cell leukemia transcription factor-2; protein G17 (PBX2, G17)

Function

• transcriptional activator that binds the sequence 5'-ATCAATCAA-3'
• activates transcription of PF4 in complex with MEIS1
• forms heterodimers with MEIS1 & heterotrimers with MEIS1 & HOXA9
• interacts with PBXIP1
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the TALE/PBX homeobox family

contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

Expression

ubiquitously expressed

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/P40425.html
• OMIM: https://mirror.omim.org/entry/176311
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5089
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5089