homeobox protein PRH; hematopoietically-expressed homeobox protein HHEX; homeobox protein HEX (PRH, HHEX, HEX, PRHX)

Function

• recognizes the DNA sequence 5'-ATTAA-3'
• transcriptional repressor
• may play a role in hematopoietic differentiation
• establishes anterior identity at two levels
  • acts early to enhance canonical WNT-signaling by repressing expression of TLE4
  • acts later to inhibit NODAL-signaling by directly targeting NODAL

Structure

contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

Expression

• expressed in liver & promyelocytic leukemia cell line HL60
• expressed during hematopoiesis

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q03014.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3087
• OMIM: https://mirror.omim.org/entry/604420