transducin-like enhancer protein 4 (TLE4, KIAA1261)

Function

• transcriptional corepressor that binds to a number of transcription factors
• inhibits transcriptional activation mediated by PAX5, CTNNB1 & TCF family members in Wnt signaling
• effects of full-length TLE family members may be modulated by association with dominant-negative AES
• homooligomer & heterooligomer with other family members
• binds PAX5, LEF1, TCF7, TCF7L1 & TCF7L2

Structure

• belongs to the WD repeat groucho/TLE family
• contains 7 WD repeats

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in all tissues examined, including brain & skeletal muscle

More general terms

• transducin-like enhancer protein (ESG)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7091
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7091
• OMIM: https://mirror.omim.org/entry/605132
• UniProt: http://www.uniprot.org/uniprot/Q04727.html