transcription factor 7-like 1 (HMG box transcription factor 3, TCF-3, TCF7L1, TCF3)

Function

• participates in the Wnt signaling pathway
• binds to DNA & acts as a repressor in the absence of CTNNB1, & as an activator in its presence
• necessary for terminal differentiation of epidermal cells, formation of keratohyalin granules & the development of barrier function of epidermis
• down-regulates NQO1, leading to increased mitomycin C resistance
• binds the armadillo repeat of CTNNB1 & forms a stable complex

Structure

• belongs to the TCF/LEF family
• contains 1 HMG box DNA-binding domain

Compartment

nucleus

Expression

• detected in hair follicles & skin keratinocytes, & at lower levels in stomach epithelium
• putative Groucho interaction domain between the N-terminal CTNNB1 binding domain & the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 & CTNNB1

More general terms

• HMG box transcription factor

Database

• OMIM: https://mirror.omim.org/entry/604652
• UniProt: http://www.uniprot.org/uniprot/Q9HCS4.html