diaphorase-4 (NADPH dehydrogenase [quinone] 1, NQO1, menadione oxidoreductase, phylloquinone oxidoreductase, quinone reductase 1, NAD(P)H:quinone oxidoreductase 1, QR1, DT-diaphorase, DTD, azoreductase, phylloquinone reductase, menadione reductase, NQO1, DIA4, NMOR1)
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Function
- quinone reductase in connection with conjugation reactions of hydroquinones i
- role in detoxification pathway
- role in biosynthetic processes including vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin (putative)
- inhibited by dicoumarol
- accepts electrons from both NADH & NADPH with equal efficiency
NADH/NADPH + a quinone <--> NAD+/NADP+ + hydroquinone
Cofactor: FAD
Structure
- homodimer
- belongs to the NADH/NADPH dehydrogenase (quinone) family
Compartment
Expression
- induced by dioxin
Pathology
- Ser-187 polymorphism may be linked to susceptibility to forms of cancers
More general terms
References
- ↑ OMIM https://mirror.omim.org/entry/125860
- ↑ UniProt http://www.uniprot.org/uniprot/P15559.html
- ↑ Atlas of Genetics & cytogenetics in oncology & Haematology http://atlasgeneticsoncology.org/Genes/NQO1ID375.html