Oxysterols receptor LXR-alpha; liver X receptor alpha; nuclear orphan receptor LXR-alpha; nuclear receptor subfamily 1 group H member 3 (NR1H3, LXRA)

Function

• ligands are oxysterols
• LXR-alpha binds to RXR to form heterodimers which bind to & activate LXRE enhancer elements
• interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRE enhancer elements
• role in regulation of cholesterol homeostasis via oxysterols
• heterodimer of LXRA & RXR

Structure

• belongs to the nuclear hormone receptor family, NR1 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• visceral organs specific expression
• expressed in liver, kidney & intestine > spleen > adrenals
• also expressed in adipose tissue, macrophages
• induced by 9-cis retinoic acid (9CRA)

More general terms

• LX nuclear receptor (LXR, oxysterol receptor)

Additional terms

• LX response element (LXRE)
• oxysterol; hydroxysterol
• retinoid X receptor (RXR)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1006
• OMIM: https://mirror.omim.org/entry/602423
• UniProt: http://www.uniprot.org/uniprot/Q13133.html