PR domain zinc finger protein 2; GATA-3-binding protein G3B; lysine N-methyltransferase 8; MTB-ZF; MTE-binding protein; PR domain-containing protein 2; retinoblastoma protein-interacting zinc finger protein; zinc finger protein RIZ (PRDM2, KMT8, RIZ)

Function

• S-adenosyl-L-methionine-dependent histone methyltransferase
• specifically methylates Lys-9 of histone H3
• may function as a DNA-binding transcription factor
• binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene & may act as a transcriptional activator of this gene
• binds to the retinoblastoma protein (RB)
• interacts withGATA3

S-adenosyl-L-methionine + L-lysine-[[[A137031|histone]]] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[[[A137031|histone]]]

Structure

• contains 8 C2H2-type Zn+2 fingers
• contains 1 SET domain

Compartment

nucleus

Alternative initiation

• named isoforms=3
• alternative initiation at Met-202 of isoform 1

Expression

• highly expressed in retinoblastoma cell lines & in brain tumors
• also expressed in a number of other cell lines & in brain, heart, skeletal muscle, liver & spleen
• isoform 1 is expressed in testis at much higher level than isoform 3

More general terms

• histone N-methyltransferase
• C2H2 type zinc finger protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7799
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7799
• OMIM: https://mirror.omim.org/entry/601196
• UniProt: http://www.uniprot.org/uniprot/Q13029.html