zinc finger protein 281; GC-box-binding zinc finger protein 1; transcription factor ZBP-99; zinc finger DNA-binding protein 99 (ZNF281, GZP1, ZBP99)

Function

• role in transcriptional regulation
• represses the transcription of a number of genes including gastrin & ornithine decarboxylase
• binds to the G-rich box in the enhancer region of these genes
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 4 C2H2-type Zn+2 fingers

Compartment

nucleus

More general terms

• C2H2 type zinc finger protein
• transcriptional silencer (transcriptional repressor)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23528
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23528
• UniProt: http://www.uniprot.org/uniprot/Q9Y2X9.html