prostaglandin E2 receptor EP4 subtype; PGE receptor, EP4 subtype; prostanoid EP4 receptor (PTGER4, PTGER2)

Function

• receptor for prostaglandin E2 (PGE2)
• activity is mediated by Gs proteins that stimulate adenylate cyclase
• has a relaxing effect on smooth muscle
• may play a role in
  • regulating renal hemodynamics
  • intestinal epithelial transport
  • adrenal aldosterone secretion
  • uterine function
• interacts with FEM1A

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• high expression in intestine & in peripheral blood mononuclear cells
• low expression in lung, kidney, thymus, uterus, vasculature & brain
• not found in liver, heart, retina or skeletal muscle

Notes

Was originally designated as the EP2 subtype

More general terms

• prostaglandin-E [PGE] receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5734
• OMIM: https://mirror.omim.org/entry/601586
• UniProt: http://www.uniprot.org/uniprot/P35408.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5734