protein fem-1 homolog A (FEM1-alpha, FEM1a, prostaglandin E receptor 4-associated protein, FEM1A, EPRAP)

Function

• probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit
• may participate in antiinflammatory signaling via its interaction with PTGER4
• component of some E3 ubiquitin-protein ligase complex
• interacts with PTGER4
• protein degradation; protein ubiquitination

Structure

• belongs to the fem-1 family
• contains 9 ANK repeats
• contains 2 TPR repeats

Compartment

cytoplasm (probable)

Expression

• present in macrophages derived from peripheral blood monocytes

Pathology

• present in atheromata (at protein level)
• frequently down-regulated in rhabdomyosarcoma

More general terms

• ankyrin repeat domain protein (ANKRD)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5552
• UniProt: http://www.uniprot.org/uniprot/Q9BSK4.html