centaurin-gamma-2; Arf-GAP with GTPase, ANK repeat & PH domain-containing protein 1; AGAP-1; Cnt-g2; GTP-binding & GTPase-activating protein 1; GGAP1 (AGAP1, CENTG2, KIAA1099)

Function

• GTPase-activating protein for ARF1 &, to a lesser extent, ARF5
• directly & specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system
• GAP activity stimulated by phosphatidylinositol-3,4,5-trisphosphate (PIP3) &, to a lesser extent, by phosphatidylinositol-4,5-bisphosphate (PIP2)
• phosphatidic acid potentiates PIP2 stimulation
• phosphorylated on Tyr
• homodimer
• interacts with several subunits of the AP-3 protein complex: AP3M1, AP3S1 & AP3S2
• interacts with GUCY1A3 & GUCY1B3

Structure

• the PH domain mediates AP-3 binding
• belongs to the centaurin gamma-like family
• contains 2 ANK repeats
• contains 1 Arf-GAP domain
• contains 1 PH domain

Compartment

• cytoplasm
  • associates with the endocytic compartment

Alternative splicing

named isoforms=3

Expression

widely expressed

More general terms

• centaurin gamma
• ankyrin repeat domain protein (ANKRD)
• phosphoprotein

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=116987
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:116987
• OMIM: https://mirror.omim.org/entry/608651
• UniProt: http://www.uniprot.org/uniprot/Q9UPQ3.html