Ephrin type-B receptor 4; hepatoma transmembrane kinase; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11 (EPHB4, HTK, TYRO11)

Function

• receptor for members of the ephrin-B family
• binds to ephrin-B2
• may have a role in events mediating differentiation & development
• autophosphorylated

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
• contains 2 fibronectin F3 modules
• contains 1 protein kinase domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

membrane

Expression

• abundantly expressed in placenta
• expressed in many normal tissues & malignant cell lines
• expressed in fetal brain, but not adult brain
• expressed in hematopoietic precursors & myeloid cells
• not expressed in lymphocytes

More general terms

• ephB receptor
• glycoprotein

Additional terms

• hepatoma

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2050
• OMIM: https://mirror.omim.org/entry/600011
• UniProt: http://www.uniprot.org/uniprot/P54760.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2050