bcl-2 homologue of ovary (Boo) or death inducer binding to vBcl-2 & Apaf-1 (Diva)

^[1]^[2]^[3]^[4]

Function

may promote or inhibit apoptosis depending on cell type^[3]
binds bcl-xL^[3]
interacts with Apaf-1 & inhibits binding of bcl-xL to Apaf-1^[1]
interacts with various pro- & anti-apoptotic bcl-2 family members
Bak & Bik disrupt Boo/Diva association with Apaf-1^[2]
in glioma cell lines, Boo/Diva promoted cell cycle exit in response to serum deprivation & inhibited apoptosis induced by CD95 ligand.
Boo/Diva interfered with apoptotic signaling downstream of cytochrome c release but upstream of caspase activation^[4]

liver, kidney, ovary

Uniprot reference for mouse protein

↑ ^1.0 ^1.1 Inohara N et al Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. J Biol Chem 273:32479-86, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9829980
↑ ^2.0 ^2.1 Song Q et al Boo, a novel negative regulator of cell death, interacts with Apaf-1. EMBO J 18:167-78, 1999 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9878060
↑ ^3.0 ^3.1 ^3.2 Lee R et al Characterization of NR13-related human cell death regulator, Boo/Diva, in normal and cancer tissues. Biochimica et Biophysica Acta 1520:187-94, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11566354
↑ ^4.0 ^4.1 Naumann U et al Diva/Boo is a negative regulator of cell death in human glioma cells. FEBS Letters 505:23-26, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11557035