uridine phosphorylase 1 (UrdPase 1, UPase 1, UPP1, UP)

Function

• reversible phosphorylytic cleavage of uridine & deoxyuridine to uracil & ribose- or deoxyribose-1-phosphate
• metabolic intermediate biosynthesis
  • 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis
  • 5-phospho-alpha-D-ribose 1-diphosphate

uridine + phosphate <--> uracil + alpha-D-ribose-1-phosphate

Structure

belongs to the PNP/UDP phosphorylase family

Alternative splicing

named isoforms=2

Expression

• induction by vitamin D3 & inflammatory cytokines: TNF-alpha, IL-1, interferon-gamma

More general terms

• uridine phosphorylase

Database

• OMIM: https://mirror.omim.org/entry/191730
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7378
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7378
• UniProt: http://www.uniprot.org/uniprot/Q16831.html