chromosomal deletion 1p32 (T-ALL)

Genetics

• chromosomal deletion at 1p32 between STIL & TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3 in some T-cell acute lymphoblastic leukemias (T-ALL)
• as both STIL exon 1 & TAL1 exon 3 are 5'-untranslated exons, STIL/TAL1 fusion mRNA predicts a full length TAL1 protein under the control of the STIL promoter, leading to inappropriate TAL1 expression

Clinical significance

• in childhood T-cell malignancies (T-ALL), the STIL/TAL1 fusion is associated with a good prognosis
• in cultured lymphocytes from healthy adults, STIL/TAL1 fusion mRNA may be detected after 7 days of culture

More general terms

• chromosomal deletion

Additional terms

• precursor T-lymphoblastic leukemia/lymphoma