SCL-interrupting locus protein (TAL-1-interrupting locus protein) (STIL SIL)
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Function
- immediate-early gene protein
- role in embryonic development, cellular growth & proliferation
- its long-term silencing affects cell survival & cell cycle distribution as well as decreases CDC2 activity correlated with reduced phosphorylation of CDC2.
- role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1
- interacts with PIN1 via its WW domain, dependent on STIL mitotic phosphorylation (putative)
- phosphorylated following the activation of the mitotic checkpoint
Compartment
Alternative splicing
named isoforms=2
Expression
- expressed in all hematopoietic tissues & cell lines
- down-regulated when cell proliferation ceases
- accumulates during G2 phase & falls at completion of the cell cycle
Pathology
- highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer
- chromosomal deletion at 1p32 between STIL & TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3 in some T-cell acute lymphoblastic leukemias (T-ALL)
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q15468.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/Genes/SILID524ch1p32.html