inclusion body myositis (inflammatory myositis, IBM)

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Etiology

* distinguishing features from polymyositis/dermatomyositis

Epidemiology

  • occurs in older patients (> 50 years)*
  • occurs more frequently in males than females*
  • most common form of myositis in patients presenting > 60 years of age[2]

* distinguishing features from polymyositis/dermatomyositis

Pathology

* distinguishing feature from polymyositis/dermatomyositis

# amyloid is cross-reactive with amyloid-beta peptide antibodies

Genetics

  • familial association

Clinical manifestations

* distinguishing features from polymyositis/dermatomyositis

Laboratory

* distinguishing feature from polymyositis/dermatomyositis

Diagnostic procedures

* distinguishing feature from polymyositis/dermatomyositis

Radiology

Complications

Differential diagnosis

Management

More general terms

Additional terms

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 877
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 15, 16, 17, 18, 19. American College of Physicians, Philadelphia 1998, 2006, 2009, 2012, 2015, 2018, 2022.
    Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  3. 3.0 3.1 3.2 3.3 Weiner S, In: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  4. LaFeria F, UCLA Brain Matters, Sept 30, 2002
  5. Needham M, Mastaglia FL. Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches. Lancet Neurol. 2007 Jul;6(7):620-31. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17582362
  6. Chahin N, Engel AG. Correlation of muscle biopsy, clinical course, and outcome in PM and sporadic IBM. Neurology. 2008 Feb 5;70(6):418-24. Epub 2007 Sep 19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17881720
  7. Amato AA, Barohn RJ. Inclusion body myositis: old and new concepts. J Neurol Neurosurg Psychiatry. 2009 Nov;80(11):1186-93 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19864656
  8. 8.0 8.1 8.2 8.3 8.4 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
  9. Amato AA, Barohn RJ. Inclusion body myositis: old and new concepts. J Neurol Neurosurg Psychiatry. 2009 Nov;80(11):1186-93. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19864656
  10. Johnson LG, Collier KE, Edwards DJ et al Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis. J Clin Neuromuscul Dis. 2009 Jun;10(4):178-84. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19494728
  11. Engel WK, Askanas V Inclusion-body myositis: clinical, diagnostic, and pathologic aspects. Neurology. 2006 Jan 24;66(2 Suppl 1):S20-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16432141
  12. Needham M, Mastaglia FL. Sporadic inclusion body myositis: A review of recent clinical advances and current approaches to diagnosis and treatment. Clin Neurophysiol. 2016 Mar;127(3):1764-73. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26778717
  13. NINDS Inclusion Body Myositis Information Page https://www.ninds.nih.gov/Disorders/All-Disorders/Inclusion-Body-Myositis-Information-Page

Patient information

inclusion body myositis patient information

Database