Herpes (pemphigoid) gestationis
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Etiology
Epidemiology
rare
Pathology
- subepidermal bulla with eosinophils
- deposition of C3 in a linear pattern along the basement membrane
- deposition of IgG along with C3 in 30-40% of cases
- circulating antibody crosses placenta
- baby born to mother may develop transient vesiculobullous dermatitis during the neonatal period
Clinical manifestations
- intensely pruritic urticarial papules, plaques or blisters
- generally occurs in last 1/2 of pregnancy
Laboratory
- biopsy: direct immunofluorescence
- serum contains 'HG factor' in 50% of patients
- labs with Loincs
- see ARUP consult[3]
Management
- topical glucocorticoids
- prednisone 20-40 mg PO QD
- newborns at risk of reversible adrenal insufficiency
More general terms
Additional terms
References
- ↑ Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 167-68
- ↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 287
- ↑ 3.0 3.1 ARUP Consult: Pemphigoid Gestationis - Herpes Gestationis The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/pemphigoid-gestationis