post coital contraception (Plan B, morning after)
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Introduction
oral contraceptives taken within 72-120 hours (5 days) of unprotected intercourse (coitus).
Indications
* doxycycline (single dose) may prevent gonorrhea, Chlamydia & syphilis[25]
Contraindications
Dosage
- 0.10-0.2 mg of ethinyl estradiol &
- 0.50-0.60 mg of levonorgestrel (Ovral)*
in each of 2 doses* separated by 12 hours.
- plan B one step: levonorgestrel 1.5 mg PO once[9] (OTC)
- less effective than ulipristal in women with BMI > 26
- 40 mg of piroxicam (by prescription only) added to levonorgestrel results in fewer pregnancies than levonorgestrel alone 0.2% vs 1.7%[24]
- ulipristal (once) is an alternative[1]
- effective in women with BMI > 26
- effective for up to 5 days after unprotected sexual intercourse[23]
- doxycycline 200 mg (single dose) within 72 hours after unprotected sexual intercourse may prevent gonorrhea, Chlamydia & syphilis[25]
* Ref 2 indicates both tablets may be taken in 1 dose
89% effective within 3 days; still useful up to 5 days[2]
Considered safe[3]
Some pharmacists may be reluctant to dispense[4]
Generic Plan B FDA approved June 2009
Copper IUD are effective as emergency contraception[12]
- may be inserted up to 5 days after unprotected sex[19]
levonorgestrel IUD non-inferior to copper IUD[22]
Monitor
- obtain pregnancy test[5]
Adverse effects
- changes in menstrual bleeding may occur; generally shorter cycles if menstrual cycle within 28 days
Mechanism of action
- does not prevent implantation[13]
- levonorgestrel & mifepristone delay ovulation[13]
- others may thicken cervical mucus, making it more difficult for sperm to reach the egg
Complications
- no adverse pregnancy outcomes associated with Plan B emergency contraception[7]
- routine use is not harmful, but is not the best choice[10]
Notes
- FDA approve OTC plan B for women 15 years of age & older[16]
- must be stocked behind the counter
- Rx for patients 14 years & younger
- American Academy of Pediatrics recommends OTC sale of Plan B to teenagers[14]
- use doubled 2002 to 2010
- reasons for use split between unprotected sex & fear that contraception would fail[15]
- intrauterine devices are most expensive to administer but most cost-effective during the first year after emergency contraception[21]
More general terms
Additional terms
Components
References
- ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 17. American College of Physicians, Philadelphia 1998, 2015
- ↑ 2.0 2.1 Prescriber's Letter 10(6):34 2003
- ↑ 3.0 3.1 Prescriber's Letter 11(1):5 2004 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200107&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 4.0 4.1 Prescriber's Letter 12(5): 2005 Pharmacist Conscience Clause Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210514&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 5.0 5.1 Raymound EG et al, Bleeding pattenrms after use of levonorgestrel emergency contraceptive pills. Contraception 2006; 73:376 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16531171
- ↑ 6.0 6.1 Prescriber's Letter 13(10): 2006 Plan B and OTC Status Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=221021&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 7.0 7.1 Zhang L et al Pregnancy outcome after levonorgestrel-only emergency contraception failure: A prospective cohort study. Hum Reprod 2009 Mar 31; [e-pub ahead of print] <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19336440 <Internet> http://dx.doi.org/10.1093/humrep/dep076
- ↑ FDA NEWS RELEASE, June 24, 2009 FDA Approves Generic Prescription-Only Version of Plan B Emergency Contraceptive for Women Ages 17 and Under http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm168870.htm
- ↑ 9.0 9.1 Plan B One-Step - Highlights of Prescribing Information Duramed Pharmaceuticals, Inc. http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021998lbl.pdf Plan B One-Step - New FDA-Approved One-Pill Emergency Contraceptive - Teva Pharmaceuticals http://planbonestep.com/pdfs/PlanBOneRelease_FINAL.pdf
ACOG Statement on Single-Dose EC Reformulation American College of Obsetricians and Gynecologists http://www.acog.org/from_home/publications/press_releases/nr07-15-09.cfm - ↑ 10.0 10.1 Prescriber's Letter 18(6): 2011 COMMENTARY: Routine Use of Emergency Contraception... Is It Safe? GUIDELINES: American College of Obstetricians and Gynecologists (ACOG). Emergency Contraception (2010) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=270612&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ Federal court order from March 2009 http://www.nyed.uscourts.gov/pub/rulings/cv/2005/05cv366mofinal.pdf
- ↑ 12.0 12.1 Cleland K et al The efficacy of intrauterine devices for emergency contraception: a systematic review of 35 years of experience Hum. Reprod. (2012) May 8 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22570193 <Internet> http://humrep.oxfordjournals.org/content/early/2012/05/02/humrep.des140.abstract?sid=4d51eb8d-0941-4dca-b81c-45042be909d1
- ↑ 13.0 13.1 13.2 Physician's First Watch, June 6, 2012 Massachusetts Medical Society
Belluck P Abortion Qualms on Morning-After Pill May Be Unfounded New York Times http://www.nytimes.com/2012/06/06/health/research/morning-after-pills-dont-block-implantation-science-suggests.html?_r=1
Marions L et al. Effect of emergency contraception with levonorgestrel or mifepristone on ovarian function. Contraception 2004 May; 69:373-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15105059 - ↑ 14.0 14.1 American Academy of Pediatrics Emergency Contraception: Committee on Adolescence Policy Statement: Emergency Contraception Pediatrics. November 26, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23184108 <Internet> http://pediatrics.aappublications.org/content/early/2012/11/21/peds.2012-2962.full.pdf+html
- ↑ 15.0 15.1 Daniels K et al Use of Emergency Contraception Among Women Aged 15-44: United States, 2006-2010 NCHS Data Brief. No 112. Feb 2013 http://www.cdc.gov/nchs/data/databriefs/db112.pdf
- ↑ 16.0 16.1 FDA News Release: April 30, 2013 FDA approves Plan B One-Step emergency contraceptive without a prescription for women 15 years of age and older. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm350230.htm
- ↑ 17.0 17.1 Reuters. Nov 26, 2013 U.S. FDA reviewing if weight limits effect of 'morning after' pill http://in.reuters.com/article/2013/11/26/us-fda-morningafter-idINBRE9AP02B20131126
- ↑ Langston A Emergency contraception: update and review. Semin Reprod Med. 2010 Mar;28(2):95-102 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20352558
- ↑ 19.0 19.1 19.2 Prescriber's Letter 21(1): 2014 Emergency Contraception: Is It Effective in Heavier Women? Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300108&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ Raymond EG and Cleland K Emergency Contraception. N Engl J Med 2015; 372:1342-1348. April 2, 2015 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25830424
Cleland K, Raymond EG, Westley E, Trussell J. Emergency contraception review: evidence-based recommendations for clinicians. Clin Obstet Gynecol. 2014 Dec;57(4):741-50 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25254919 - ↑ 21.0 21.1 Bellows BK, Tak CR, Sanders JN, Turok DK, Schwarz EB. Cost-effectiveness of emergency contraception options over 1 year. Am J Obstet Gynecol 2018 May; 218:508.e1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29409847
- ↑ 22.0 22.1 Turok DK, Gero A, Simmons RG et al Levonorgestrel vs. Copper Intrauterine Devices for Emergency Contraception. N Engl J Med 2021; 384:335-344. Jan 28. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33503342 https://www.nejm.org/doi/full/10.1056/NEJMoa2022141
- ↑ 23.0 23.1 Woodhams EJ, Gilliam M. Contraception. Ann Intern Med. 2019;170:ITC18-ITC32. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30716758
- ↑ 24.0 24.1 Li RHW et al. Oral emergency contraception with levonorgestrel plus piroxicam: A randomised double-blind placebo-controlled trial. Lancet 2023 Sep; 402:851 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37597523 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01240-0/fulltext
- ↑ 25.0 25.1 25.2 Branswell H CDC proposes new antibiotics policy aimed at reducing STIs. STAT Health. Oct 2, 2023 https://www.statnews.com/2023/10/02/cdc-proposes-new-antibiotics-policy-aimed-at-reducing-stis/