post coital contraception (Plan B, morning after)

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Introduction

oral contraceptives taken within 72-120 hours (5 days) of unprotected intercourse (coitus).

Indications

* doxycycline (single dose) may prevent gonorrhea, Chlamydia & syphilis[25]

Contraindications

  • may not be effective in women > 165-175 pounds[19]

Dosage

in each of 2 doses* separated by 12 hours.

* Ref 2 indicates both tablets may be taken in 1 dose

89% effective within 3 days; still useful up to 5 days[2]

Considered safe[3]

OTC soon, cost $30 or more[6]

Some pharmacists may be reluctant to dispense[4]

Generic Plan B FDA approved June 2009

Copper IUD are effective as emergency contraception[12]

  • may be inserted up to 5 days after unprotected sex[19]

levonorgestrel IUD non-inferior to copper IUD[22]

Monitor

Adverse effects

Mechanism of action

Complications

Notes

More general terms

Additional terms

Components

References

  1. 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 17. American College of Physicians, Philadelphia 1998, 2015
  2. 2.0 2.1 Prescriber's Letter 10(6):34 2003
  3. 3.0 3.1 Prescriber's Letter 11(1):5 2004 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200107&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. 4.0 4.1 Prescriber's Letter 12(5): 2005 Pharmacist Conscience Clause Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210514&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 Raymound EG et al, Bleeding pattenrms after use of levonorgestrel emergency contraceptive pills. Contraception 2006; 73:376 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16531171
  6. 6.0 6.1 Prescriber's Letter 13(10): 2006 Plan B and OTC Status Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=221021&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. 7.0 7.1 Zhang L et al Pregnancy outcome after levonorgestrel-only emergency contraception failure: A prospective cohort study. Hum Reprod 2009 Mar 31; [e-pub ahead of print] <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19336440 <Internet> http://dx.doi.org/10.1093/humrep/dep076
  8. FDA NEWS RELEASE, June 24, 2009 FDA Approves Generic Prescription-Only Version of Plan B Emergency Contraceptive for Women Ages 17 and Under http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm168870.htm
  9. 9.0 9.1 Plan B One-Step - Highlights of Prescribing Information Duramed Pharmaceuticals, Inc. http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021998lbl.pdf Plan B One-Step - New FDA-Approved One-Pill Emergency Contraceptive - Teva Pharmaceuticals http://planbonestep.com/pdfs/PlanBOneRelease_FINAL.pdf
    ACOG Statement on Single-Dose EC Reformulation American College of Obsetricians and Gynecologists http://www.acog.org/from_home/publications/press_releases/nr07-15-09.cfm
  10. 10.0 10.1 Prescriber's Letter 18(6): 2011 COMMENTARY: Routine Use of Emergency Contraception... Is It Safe? GUIDELINES: American College of Obstetricians and Gynecologists (ACOG). Emergency Contraception (2010) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=270612&pb=PRL (subscription needed) http://www.prescribersletter.com
  11. Federal court order from March 2009 http://www.nyed.uscourts.gov/pub/rulings/cv/2005/05cv366mofinal.pdf
  12. 12.0 12.1 Cleland K et al The efficacy of intrauterine devices for emergency contraception: a systematic review of 35 years of experience Hum. Reprod. (2012) May 8 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22570193 <Internet> http://humrep.oxfordjournals.org/content/early/2012/05/02/humrep.des140.abstract?sid=4d51eb8d-0941-4dca-b81c-45042be909d1
  13. 13.0 13.1 13.2 Physician's First Watch, June 6, 2012 Massachusetts Medical Society
    Belluck P Abortion Qualms on Morning-After Pill May Be Unfounded New York Times http://www.nytimes.com/2012/06/06/health/research/morning-after-pills-dont-block-implantation-science-suggests.html?_r=1
    Marions L et al. Effect of emergency contraception with levonorgestrel or mifepristone on ovarian function. Contraception 2004 May; 69:373-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15105059
  14. 14.0 14.1 American Academy of Pediatrics Emergency Contraception: Committee on Adolescence Policy Statement: Emergency Contraception Pediatrics. November 26, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23184108 <Internet> http://pediatrics.aappublications.org/content/early/2012/11/21/peds.2012-2962.full.pdf+html
  15. 15.0 15.1 Daniels K et al Use of Emergency Contraception Among Women Aged 15-44: United States, 2006-2010 NCHS Data Brief. No 112. Feb 2013 http://www.cdc.gov/nchs/data/databriefs/db112.pdf
  16. 16.0 16.1 FDA News Release: April 30, 2013 FDA approves Plan B One-Step emergency contraceptive without a prescription for women 15 years of age and older. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm350230.htm
  17. 17.0 17.1 Reuters. Nov 26, 2013 U.S. FDA reviewing if weight limits effect of 'morning after' pill http://in.reuters.com/article/2013/11/26/us-fda-morningafter-idINBRE9AP02B20131126
  18. Langston A Emergency contraception: update and review. Semin Reprod Med. 2010 Mar;28(2):95-102 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20352558
  19. 19.0 19.1 19.2 Prescriber's Letter 21(1): 2014 Emergency Contraception: Is It Effective in Heavier Women? Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300108&pb=PRL (subscription needed) http://www.prescribersletter.com
  20. Raymond EG and Cleland K Emergency Contraception. N Engl J Med 2015; 372:1342-1348. April 2, 2015 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25830424
    Cleland K, Raymond EG, Westley E, Trussell J. Emergency contraception review: evidence-based recommendations for clinicians. Clin Obstet Gynecol. 2014 Dec;57(4):741-50 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25254919
  21. 21.0 21.1 Bellows BK, Tak CR, Sanders JN, Turok DK, Schwarz EB. Cost-effectiveness of emergency contraception options over 1 year. Am J Obstet Gynecol 2018 May; 218:508.e1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29409847
  22. 22.0 22.1 Turok DK, Gero A, Simmons RG et al Levonorgestrel vs. Copper Intrauterine Devices for Emergency Contraception. N Engl J Med 2021; 384:335-344. Jan 28. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33503342 https://www.nejm.org/doi/full/10.1056/NEJMoa2022141
  23. 23.0 23.1 Woodhams EJ, Gilliam M. Contraception. Ann Intern Med. 2019;170:ITC18-ITC32. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30716758
  24. 24.0 24.1 Li RHW et al. Oral emergency contraception with levonorgestrel plus piroxicam: A randomised double-blind placebo-controlled trial. Lancet 2023 Sep; 402:851 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37597523 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01240-0/fulltext
  25. 25.0 25.1 25.2 Branswell H CDC proposes new antibiotics policy aimed at reducing STIs. STAT Health. Oct 2, 2023 https://www.statnews.com/2023/10/02/cdc-proposes-new-antibiotics-policy-aimed-at-reducing-stis/