retinal homeobox protein Rx; retina & anterior neural fold homeobox protein (RAX, RX)

Function

• role in eye formation by regulating the initial specification of retinal cells &/or their subsequent proliferation
• binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter

Structure

• belongs to the paired homeobox family, Bicoid subfamily
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Expression

• expressed in the developing eye
• weakly expressed in the adult retina

Pathology

• defects in RAX are the cause of microphthalmia isolated type 3

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30062
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:30062
• OMIM: https://mirror.omim.org/entry/601881
• OMIM: https://mirror.omim.org/entry/611038
• UniProt: http://www.uniprot.org/uniprot/Q9Y2V3.html