ulipristal acetate (Ella)

^[1]^[2]^[3]^[4]^[5]

Introduction

FDA-approved Aug 2010, available only by prescription

emergency contraceptive (plan B)
for use within 120 hours (5 days) after failure of standard contraception or after unprotected intercourse
hemorrhage due to uterine fibroids^[4]

progesterone agonist/antagonist that works mainly by inhibiting or delaying ovulation

↑ Glasier AF et al Ulipristal acetate versus levonorgestrel for emergency contraception: A randomised non-inferiority trial and meta- analysis. Lancet 2010 Feb 13; 375:555. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20116841
↑ FDA NEWS RELEASE, August 13, 2010 FDA approves ella <TM> tablets for prescription emergency contraception http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm222428.htm
↑ Prescriber's Letter 17(10): 2010 Ella (Ulipristal) for Emergency Contraception Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=261008&pb=PRL (subscription needed) http://www.prescribersletter.com
↑ ^4.0 ^4.1 Donnez J et al. Ulipristal acetate versus placebo for fibroid treatment before surgery. N Engl J Med 2012 Feb 2; 366:409. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22296075
Donnez J et al. Ulipristal acetate versus leuprolide acetate for uterine fibroids. N Engl J Med 2012 Feb 2; 366:421. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22296076
Stewart EA. Uterine fibroids and evidence-based medicine-Not an oxymoron. N Engl J Med 2012 Feb 2; 366:471. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22296082
↑ ^5.0 ^5.1 Prescriber's Letter 21(6): 2014 Oral Meds to Keep in Original Containers Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300622&pb=PRL (subscription needed) http://www.prescribersletter.com