RNA polymerase II elongation factor ELL; eleven-nineteen lysine-rich leukemia protein (ELL, C19orf17)

Function

• transcription elongation factor
• can increase the catalytic rate of RNA polymerase 2 transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with EAF1 & EAF2

Structure

belongs to the ELL/occludin family

Compartment

• nuclear speckle, nucleus, Cajal body
• colocalizes with EAF2 to nuclear speckles
• also localized to Cajal (coiled) bodies

Expression

• expressed in all tissues tested
• highest levels found in placenta, skeletal muscle, testis & peripheral blood leukocytes

Pathology

• chromosomal translocation t(11;19)(q23;p13.1) involving ELL with MLL/HRX is found in acute leukemias
• the result is a rogue activator protein

More general terms

• nuclear protein
• proto oncogene protein
• phosphoprotein

Additional terms

• RNA polymerase-2

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8178
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8178
• OMIM: https://mirror.omim.org/entry/600284
• UniProt: http://www.uniprot.org/uniprot/P55199.html