rabenosyn-5; FYVE finger-containing Rab5 effector protein rabenosyn-5; zinc finger FYVE domain-containing protein 20; 110 kD protein (ZFYVE20)

Function

• Rab4/Rab5 effector protein
• early endocytic membrane fusion & membrane trafficking of recycling endosomes
• required for endosome fusion either homotypically or with clathrin coated vesicles
• role in the lysosomal trafficking of cathepsin D from Golgi to lysosomes
• promotes recycling of transferrin directly from early endosomes to plasma membrane
• binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3)
• interacts with EHD1, RAB4A, RAB5A, RAB22A, RAB24, VPS45
• binds simultaneously to RAB4A & RAB5A in vitro
• interacts with RAB4A & RAB5A activated by GTP binding

Structure

• contains 1 C2H2-type zinc finger
• contains 1 FYVE-type zinc finger
• contains 1 UIM repeat (ubiquitin-interacting motif)

Compartment

• cell membrane, lipid-anchor, cytoplasmic side
• early endosomal membrane, lipid- anchor

More general terms

• zinc finger FYVE domain-containing protein (ZFYVE)
• membrane protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H1K0.html