rab24 proto-oncogene protein; Ras-related protein Rab-24 (RAB24)

Function

• may be involved in autophagy-related processes
• unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA & ARHGDIB
• isoprenylation is inefficient compared to other Rab family members

Structure

• belongs to the small GTPase superfamily, Rab family
• the unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity; as a result, the predominant nucleotide associated with RAB24 is GTP

Compartment

• cytoplasm
• membrane; lipid-anchor
• only about 20-25% is recovered in the particulate fraction

Expression

• induced by extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level)

More general terms

• rab subfamily protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q969Q5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53917
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53917
• OMIM: https://mirror.omim.org/entry/612415