ECS complex; elonginB/C-CUL2/5-SOCS-box protein complex; ECS E3 ubiquitin-protein ligase complex

Function

• E3 ubiquitin-protein ligase complex
• mediates ubiquitination of target proteins
• may serve as a rigid scaffold in the complex
• may contribute to catalysis through positioning of the substrate & the ubiquitin-conjugating enzyme
• E3 ubiquitin-protein ligase activity is dependent on neddylation of the cullin subunit & is inhibited by association of the deneddylated cullin with TIP120A/CAND1 (putative)
• functional specificity of the ECS complex depends on the substrate recognition component

Structure

• subunits include CUL2, elongin BC (TCEB1 & TCEB2), RBX1 & a variable substrate-specific adapter

More general terms

• molecular complex

More specific terms

• ECS(ASB1) complex
• ECS(ASB2) complex
• ECS(ASB4) complex
• ECS(MED8) complex
• ECS(PPIL5) complex
• ECS(VHL) complex
• ECS(WSB1) complex

Additional terms

• CBC(VHL) complex
• elongin BC complex