perioperative clonidine

Introduction

perioperative clonidine reduces mortality

Dosage

• 0.2 mg clonidine on night before & morning of surgery &
  • 0.2 mg transdermal patch removed on day 4

Benefits:

• reduces hypertension > 18 mm Hg (25% vs 48%)
  • no increase in hypotension
• reduces perioperative ischemia (no difference in in-hospital myocardial infarction)
• reduces mortality
  • 30 -day (1% vs 6%) & 2-year (15% vs 29%)