Rho(D) immune globulin (Gamulin Rh, HypRho-D MICRhoGAM, MiniGamulin Rh, Rhesonativ, RhoGAM, WinRho)

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Indications

Contraindications

Caution:

pregnancy-category C

safety in lactation ?

Benefit/risk

Dosage

Obstetrical:

Postpartum prophylaxis:

  • 1 vial (300 ug) IM within 72 hours of delivery

Antepartum prophylaxis:

Following miscarriage, abortion, or termination of ectopic pregnancy:

  • up to 13 weeks of gestation:
    • 50 ug IM within 3 hours, but may be given up to 72 hours later
  • after 13 week of gestation: 300 ug IM

Injection:

  • (RhoGAM, HypRho-D) each vial contains 300 ug
  • MICRhoGAM each vial contains 50 ug

Pharmacokinetics

elimination: liver

Adverse effects

Notes

More general terms

Additional terms

References

  1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  2. 2.0 2.1 FDA Medwatch http://www.fda.gov/medwatch/safety/2006/safety06.htm#WinRho
  3. 3.0 3.1 3.2 The NNT: Anti-D (Rh Factor) Administration During Late Pregnancy for the Prevention of Alloimmunization in At-Risk Women. http://www.thennt.com/nnt/rhogam-in-late-pregnancy-for-prevention-of-sensitization-in-at-risk-women/
    The NNT: Anti-D (Rh Factor) Immunoglobulin Administration Postpartum for the Prevention of Alloimmunization in At-Risk Women. http://www.thennt.com/nnt/rhogam-postpartum-for-prevention-of-sensitization-in-at-risk-women/
    Crowther C, Middleton P. Anti-D administration after childbirth for preventing Rhesus alloimmunisation. Cochrane Database Syst Rev. 2000;(2):CD000021. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10796089