HSPA8-interacting micropeptide miPEP155; P155 (MIR155HG)

Function

• negatively regulates MHC class II antigen presentation in dendritic cells by interacting with the molecular chaperone HSPA8 & impairing its role in lysosomal antigen transport
• does not regulate the levels or activity of the MIR155HG microRNA from which miPEP155 is derived
• interacts with molecular chaperone HSPA8/HSC70 (via N-terminal ATP-binding region)
  • the interaction results in reduced ATPase activity of HSPA8, impaired interaction of HSPA8 with HSP90 & reduced lysosomal antigen trafficking

Compartment

• cytoplasm, nucleus

Expression

• detected in dendritic cells (at protein level)
• up-regulated in antigen-presenting cells in inflamed dermis

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/C0HMA1.html