Figure: adrenal steroid biosynthesis
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Biochemistry
- steroid biosynthesis 9 :enzyme multienzyme-complex
- steroid-21-hydroxylase, cytochrome P450 reductase :substrate progesterone + O2 + NADPH :product deoxycorticosterone + NADP
- steroid biosynthesis 10 :enzyme multienzyme-complex
- steroid-21-hydroxylase, cytochrome P450 reductase :substrate 17-hydroxyprogesterone + O2 + NADPH :product 11-deoxycortisol + NADP
- steroid biosynthesis 11 :enzyme multienzyme-complex
- steroid-11-hydroxylase, adrenodoxin, adrenodoxin reductase :substrate deoxycorticosterone + O2 + NADPH :product corticosterone + NADP
- steroid biosynthesis 12 :enzyme multienzyme-complex
- steroid-11-hydroxylase, adrenodoxin, adrenodoxin reductase :substrate 11_deoxycortisol + O2 + NADPH :product cortisol + NADP)
- steroid biosynthesis 13 :enzyme multienzyme-complex
- steroid-11-hydroxylase, adrenodoxin, adrenodoxin reductase :substrate corticosterone + O2 + NADPH :product aldosterone + NADP