tau positron emission tomography (tau PET ([18F]RO948), tau PET)

^[1]^[2]^[3]

Indications

useful when added to an already extensive diagnostic workup that included CSF biomarkers for Alzheimer's disease
most useful in patients positive for beta-amyloid^[1]
tau PET predicts cognitive change better than amyloid PET & MRI^[3]
- tau PET may support prognosis in preclinical & prodromal stages of AD
tau PET outperforms amyloid PET or brain MRI in predicting conversion of mild cognitive impairment to dementia^[2]
increased 18F flortaucipir (FTP) tau PET levels associated with declines in all cognitive domains
only quantitative temporal tau PET improves prediction of all-cause dementia in patients with mild cognitive impairment^[2]

↑ ^1.0 ^1.1 Smith R et al. Clinical utility of tau positron emission tomography in the diagnostic workup of patients with cognitive symptoms. JAMA Neurol 2023 Jul; 80:749; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/37213093 PMCID: PMC10203972 Free PMC article https://jamanetwork.com/journals/jamaneurology/fullarticle/2805318
↑ ^2.0 ^2.1 ^2.2 Groot C, Smith R, Collij LE et al. Tau positron emission tomography for predicting dementia in individuals with mild cognitive impairment. JAMA Neurol 2024 Aug; 81:845-856 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38857029 PMCID: PMC11165418 Free PMC article https://jamanetwork.com/journals/jamaneurology/fullarticle/2819811
↑ ^3.0 ^3.1 Ossenkoppele R, Smith R, Mattsson-Carlgren N et al Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease. A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging. JAMA Neurol. Published online June 28, 2021. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34180956 https://jamanetwork.com/journals/jamaneurology/fullarticle/2781465