disease interaction(s) of depression with dementia
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Introduction
Interactions:
- depression may masquerade as dementia (see depressive pseudodementia)
- dementia may confound the diagnosis of depression
- depression is common in demented patients
- depression may increase risk of dementia[2]
- risk higher for men than women
Management
- nonpharmacological interventions, with or without medications, are more effectve for improving symptoms of depression in patients with dementia than medications alone[1]
- cognitive stimulation*
- massage/touch therapy*
- occupational therapy
- exercise +/- social interaction*
- reminiscence therapy +/- psychotherapy
- animal therapy
- environmental modification[1]
* massage/touch therapy, exercise with social interaction + cognitive stimulation, & cognitive stimulation + cholinesterase inhibitor may be best options [[1]
More general terms
References
- ↑ 1.0 1.1 1.2 Watt JA et al. Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: Systematic review and network meta-analysis. BMJ 2021 Mar 24; 372:n532. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33762262 PMCID: PMC7988455 Free PMC article https://www.bmj.com/content/372/bmj.n532
- ↑ 2.0 2.1 Elser H, Horvath-Puho E, Gradus JL et al Association of Early-, Middle-, and Late-Life Depression With Incident Dementia in a Danish Cohort. JAMA Neurol. Published online July 24, 2023. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37486689 https://jamanetwork.com/journals/jamaneurology/article-abstract/2807208