microplastics & nanoplastics

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Introduction

Tiny bits of plastic.

Classification

  • microplastics: > 1-5 uM
  • nanoplastics: 1-5 uM

Epidemiology

  • plastics detected in or excreted from the human body[7]
    • polyamide, polyurethane, polyethylene, polyethylene terephthalate, polypropylene, polyvinyl chloride, polyoxymethylene, ethylene-vinyl acetate, polytetrafluoroethylene, chlorinated polyethylene, polybutadiene, polycarbonate, polystyrene, polymethyl methacrylate, polylactic acid. polysulfones, nitrocellulose
micro or nanoplastic placenta meconium breast milk blood feces
polyamide x x x x x
polyurethane x x x x x
polyethylene x x x x x
polyethylene terephthalate x x x x x
polypropylene x x x x x
polyvinyl chloride x x x x x
polyoxymethylene x x x - x
ethylene-vinyl acetate x x x - x
polytetrafluoroethylene x x x - x
chlorinated polyethylene x x x - x
polybutadiene x x x - x
polycarbonate x - - x -
polystyrene x - x x x
polymethyl methacrylate x x x x x
polylactic acid x x x - x
polysulfones x x x - x*
nitrocellulose - - x - -*

* x indicates micro or nanoplastic has been detected

* - indicates micro or nanoplastic has not been detected in tissue type[7]

* polyethylene is the dominant micro or nanoplastic found in human kidney, liver & brain[6]*

* brain tissues contain higher proportions of polyethylene vs micro or nanoplastics in liver or kidney[6]

* micro or nanoplastic are present largely as nanoscale shard-like fragments

* ~10 grams of microplastics can be isolated from a donated human brain[13]

* greater accumulation of micro or nanoplastics is found in decedent brains with documented dementia, deposition in cerebrovascular walls & inflammatory cells[6]

  • size of plastics detected in or excreted from the human body[7]
placenta meconium breast milk blood feces
5-10 uM/50-240 nM > 50 uM 2-5 uM >= 700 nM adult:50-500 uM*

* size of plastics in infant feces: 20-50 uM

placenta meconium breast milk blood feces
5-10 uM/50-240 nM > 50 uM 2-5 uM >= 700 nM adult:50-500 uM*

* size of plastics in infant feces: 20-50 uM

Pathology

* study design did not allow for detection of nanoplastics[8]

Physiology

Adverse effects

Laboratory

  • microplastic in water may be detected 1-5000 uM range[12]

More general terms

References

  1. Jump up to: 1.0 1.1 World Health Organization (WHO). 2019 Microplastics in drinking-water https://www.who.int/water_sanitation_health/publications/microplastics-in-drinking-water/en/
  2. Jump up to: 2.0 2.1 Marfella R, Prattichizzo F, Sardu C et al Microplastics and Nanoplastics in Atheromas and Cardiovascular Events. N Engl J Med. 2024 Mar 7;390(10):900-910. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38446676 https://www.nejm.org/doi/full/10.1056/NEJMoa2309822
  3. Jump up to: 3.0 3.1 Krause S, Ouellet V, Allen D et al The potential of micro- and nano-plastics to exacerbate the health impacts and global burden of non-communicable diseases. Cell Rep Med. 2024 Jun 18;5(6):101581 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38781963 PMCID: PMC11228470 Free PMC article. Review.
  4. Chandra R, Sokratian A, Chavez KR et al Gut mucosal cells transfer alpha-synuclein to the vagus nerve. JCI Insight. 2023 Dec 8;8(23):e172192. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38063197 PMCID: PMC10795834 Free PMC article.
  5. Jump up to: 5.0 5.1 Liu Z, Sokratian A, Duda AM et al Anionic nanoplastic contaminants promote Parkinson's disease-associated alpha- synuclein aggregation Sci Adv. 2023 Nov 15;9(46):eadi8716. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37886561 PMCID: PMC10656074 Free PMC article.
  6. Jump up to: 6.0 6.1 6.2 6.3 6.4 Campen M, Nihart A, Garcia M et al Bioaccumulation of Microplastics in Decedent Human Brains Assessed by Pyrolysis Gas Chromatography-Mass Spectrometry. Res Sq. Preprint. 2024 May 6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100893/
    Nihart AJ, Garcia MA, El Hayek E et al Bioaccumulation of microplastics in decedent human brains. Nat Med. 2025 Feb 3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39901044 https://www.nature.com/articles/s41591-024-03453-1
  7. Jump up to: 7.0 7.1 7.2 7.3 Krause S, Ouellet V, Allen D et al The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases. Cell Rep Med. 2024 Jun 18;5(6):101581. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38781963 PMCID: PMC11228470 Free PMC article. Review.
  8. Jump up to: 8.0 8.1 8.2 8.3 Amato-Lourenco LF et al Microplastics in the Olfactory Bulb of the Human Brain. JAMA Netw Open. 2024;7(9):e2440018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/39283733 PMCID: PMC11406405 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/282378
  9. Jump up to: 9.0 9.1 Park JH, Hong S, Kim OH, Kim CH, Kim J, Kim JW, Hong S, Lee HJ. Polypropylene microplastics promote metastatic features in human breast cancer. Sci Rep. 2023 Apr 17;13(1):6252. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37069244 PMCID: PMC10108816 Free PMC article.
  10. Moulun AG Health Impacts of Micro- and Nanoplastics Medscape. December 13, 2024 https://www.medscape.com/viewarticle/health-impacts-micro-and-nanoplastics-2024a1000n1v
  11. Jump up to: 11.0 11.1 Brauser D Microplastics Have Been Found in the Human Brain. Now What? Medscape. November 27, 2024 https://www.medscape.com/viewarticle/microplastics-have-been-found-human-brain-now-what-2024a1000ln0
    Amato-Lourenco LF, Dantas KC, Junior GR et al Microplastics in the Olfactory Bulb of the Human Brain. JAMA Netw Open. 2024 Sep 3;7(9):e2440018. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39283733 PMCID: PMC11406405 Free PMC article.
  12. Jump up to: 12.0 12.1 12.2 12.3 Hagelskjaer O et al Majority of potable water microplastics are smaller than the 20 uM EU methodology limit for consumable water quality. PLOS. Water. 2025. Jan 15. Not indexed in PubMed https://journals.plos.org/water/article?id=10.1371/journal.pwat.0000250
  13. Jump up to: 13.0 13.1 Kozlov M Your brain is full of microplastics: are they harming you? Nature News. Feb 11, 2025 https://www.nature.com/articles/d41586-025-00405-8
    Kozlov M HOW ARE MICROPLASTICS AFFECTING OUR HEALTH? Nature Feature. Feb 13, 2025

Patient information

microplastics patient information