transcranial neurostimulation
Jump to navigation
Jump to search
Introduction
Manipulation of primary memory, synonymous with mental control.
Pathology
- damage to the prefrontal cortex results in impaired working memory
- working memory declines in older adults (60-76 years vs 20-29 years)[2]
- deficits are linked to desynchronization of rhythmic activity between the prefrontal regions that evaluate information & the temporal regions that store it
Diagnostic procedures
- electroencephalography (EEG)
- age-related working-memory deficits are associated with uncoupling of frontotemporal theta (4-8 Hz) & left temporal theta-gamma (> 25 Hz) phase amplitudes on EEG[2]
Complications
- negative effects of long-term, repeated application of transcranial neurostimulation or its usefulness in real world applications is unknown[2]
Management
- targeted high-definition transcranial alternating-current stimulation tuned to individual brain network dynamics for 25 minutes rapidly normalizes cortical-rhythm disruptions, restoring phase synchronization typical of younger adults[2]
- phase coordination associated with improvement in accuracy of working memory, persisting at least 50-minutes poststimulation[2]
- transcranial direct current stimulation activating the right prefrontal cortex might enhance creative thinking[2]
- transcranial alternating-current stimulation can improve both short-term memory & long-term memory for at least 1 month in older adults, including elderly with mild cognitive impairment[3]
More general terms
More specific terms
References
- ↑ Reinhart RMG, Nguyen JA. Working memory revived in older adults by synchronizing rhythmic brain circuits. Nat Neurosci 2019 Apr 8; PMID: https://www.ncbi.nlm.nih.gov/pubmed/30962628 https://www.nature.com/articles/s41593-019-0371-x
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Hertenstein E, Waibelb E, Frase L et al. Modulation of creativity by transcranial direct current stimulation. Brain Stimul 2019 Jun 5 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31231043 https://www.brainstimjrnl.com/article/S1935-861X(19)30229-3/fulltext
- ↑ 3.0 3.1 Brooks M Noninvasive Brain Stimulation May Boost Memory for at Least 4 Weeks. Medscape. August 23, 2022 https://www.medscape.com/viewarticle/979649
Grover S, Wen W, Viswanathan V et al Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation. Nature Neuroscience. 2022. 25, pages 1237-1246. August 22. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35995877 https://www.nature.com/articles/s41593-022-01132-3