transcranial direct current stimulation (tDCS)
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Indications
- depression in combination with serotinin reuptake inhibitor (SSRI)[1]
- more effective alone than placebo, but less effective than escitalopram[2]
- may be useful for treatment of aphasia after stroke[3]
Clinical significance
- stimulation of diminished right dorsolateral prefrontal cortex activity & reduction of hemispheric imbalance in depression
- transcranial direct current stimulation activating the right prefrontal cortex might enhance creative thinking[4]
Procedure
- application of weak direct current that runs from an anode electrode over the left dorsolateral prefrontal cortex to a cathode electrode over the right dorsolateral prefrontal cortex Principal:
- current from anode to left dorsolateral prefrontal cortex increases cortical excitability
- current to cathode from right dorsolateral prefrontal cortex decreases cortical excitability
More general terms
References
- ↑ 1.0 1.1 Brunoni AR et al. The Sertraline vs Electrical Current Therapy for Treating Depression Clinical Study: Results from a factorial, randomized, controlled trial. JAMA Psychiatry 2013 Feb 6 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23389323 <Internet> http://archpsyc.jamanetwork.com/article.aspx?articleid=1568955
- ↑ 2.0 2.1 Brunoni AR, Moffa AH, Sampaio-Junior B, Borrione L et al. Trial of electrical direct-current therapy versus escitalopram for depression. N Engl J Med 2017 Jun 29; 376:2523-2533 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28657871 <Internet> http://www.nejm.org/doi/10.1056/NEJMoa1612999
- ↑ 3.0 3.1 Fridriksson J, Rorden C, Elm J et al Transcranial Direct Current Stimulation vs Sham Stimulation to Treat Aphasia After Stroke. A Randomized Clinical Trial JAMA Neurol. Published online August 20, 2018. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30128538 https://jamanetwork.com/journals/jamaneurology/fullarticle/2696529
- ↑ 4.0 4.1 Hertenstein E, Waibelb E, Frase L et al. Modulation of creativity by transcranial direct current stimulation. Brain Stimul 2019 Jun 5 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31231043 https://www.brainstimjrnl.com/article/S1935-861X(19)30229-3/fulltext