sodium phosphate (NaH2PO4)

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^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]^[10]

Indications

Contraindications

rectal sodium phosphate contraindicated in children < 2 years of age^[10]

Dosage

IV dosing
- give dose based on sodium & phosphate levels
see bowel preparation

Injection:

3 mmol of phosphate/mL (15 mL);
MUST BE DILUTED PRIOR TO ADMINISTRATION

Adverse effects

not common (1-10%)
- edema, hypotension, hyperphosphatemia*, hypocalcemia*, hypernatremia, calcium phosphate precipitation, nausea/vomiting, diarrhea, acute renal failure^[6], chronic renal failure*, seizures#

* phosphate toxicity can result in hypocalcemic tetany^[3] & chronic renal failure^[4]^[6]^[7] risk of acute phosphate nephropathy is low^[5]

More general terms

More specific terms

Visicol (sodium phosphate)

Additional terms

Component of

References

↑ Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
↑ ^{Jump up to: 3.0} ^3.1 Medications Can Cause Seizures Prescriber's Letter 10(3):16 2003 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=190320&pb=PRL (subscription needed) http://www.prescribersletter.com
↑ ^{Jump up to: 4.0} ^4.1 Markowitz GS, Stokes MB, Radhakrishnan J, D'Agati VD. Acute phosphate nephropathy following oral sodium phosphate bowel purgative: an underrecognized cause of chronic renal failure. J Am Soc Nephrol. 2005 Nov;16(11):3389-96. Epub 2005 Sep 28. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16192415
↑ ^{Jump up to: 5.0} ^5.1 Russman S et al, Risk of impaired renal function after colonoscopy: A cohort study of patients receiving either oral sodium phosphoate or polyethylene glycol. Am J Gastroenterol 2007, 102:2655 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17970832
↑ ^{Jump up to: 6.0} ^6.1 ^6.2 Prescriber's Letter 15(5): 2008 Kidney Damage from Sodium Phosphate Bowel Preps Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=240505&pb=PRL (subscription needed) http://www.prescribersletter.com
↑ ^{Jump up to: 7.0} ^7.1 FDA MedWatch http://www.fda.gov/medwatch/safety/2008/safety08.htm#OSP
↑ ^{Jump up to: 8.0} ^8.1 Prescriber's Letter 16(1): 2009 Oral Sodium Phosphate Products for Bowel Cleansing: More Safety Concerns Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=250114&pb=PRL (subscription needed) http://www.prescribersletter.com
↑ ^{Jump up to: 9.0} ^9.1 ^9.2 Deprecated Reference
↑ ^{Jump up to: 10.0} ^10.1 FDA MedWatch. Jan 8, 2014 Sodium Phosphate Over-the-Counter Products: Drug Safety Communication - Possible Harm From Exceeding Recommended Dose. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm380833.htm

Database

PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24204

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