zinc sulfate (ZnSO4, Zintrace)

Indications

• zinc supplement for zinc deficiency
• may promote wound healing in patients with pressure ulcers
• prophylaxis & treatment of the common cold
  • zinc lozenges (within 24 hours of onset)
  • supplementation for at least 5 months (prophylaxis)
• acrodermatitis enteropathica

Dosage

• RDA: 15 mg elemental Zn+2/day
• zinc deficiency: 110-220 mg (25-50 mg elemental Zn+2) TID

Injection: 1 mg/mL (10 mL).

Pharmacokinetics

• poor (20-30%) absorption from GI tract
• elimination mostly in feces

Adverse effects

• uncommon (< 1%)
  • indigestion, nausea/vomiting, neutropenia, leukopenia, hypotension, jaundice, pulmonary edema

Drug interactions

• tetracycline: decreased effect of tetracycline
• iron, bran products, dairy products: reduced absorption of Zn+2

• drug interaction(s) of diuretics in combination with Zn+2

Mechanism of action

• cofactor for more than 70 enzymes

More general terms

• zinc supplement

Additional terms

• Zn+2

Component of

• polyethylene glycol/tetrahydrozoline/zinc sulfate
• ascorbate/echinacea/zinc sulfate
• phenylephrine/zinc sulfate
• hydroxypropyl methylcellulose/zinc sulfate
• hydroxypropyl methylcellulose/naphazoline/polysorbate/zinc sulfate
• glycerol/naphazoline/zinc sulfate
• glycerol/naphazoline/zinc/zinc sulfate
• glycerol/hydroxypropyl methylcellulose/polyethylene glycol/tetrahydrozoline/zinc sulfate
• copper sulfate/manganese sulfate/selenious acid/zinc sulfate
• copper sulfate/manganese chloride/selenious acid/zinc sulfate
• copper/copper sulfate/manganese/manganese sulfate/zinc sulfate
• cobalamin/magnesium sulfate/manganese sulfate/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/zinc sulfate
• cobalamin/magnesium sulfate/manganese/manganese sulfate/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/zinc sulfate
• chromous chloride/copper sulfate/manganese sulfate/selenious acid/zinc sulfate
• chromic chloride/copper sulfate/manganese sulfate/selenious acid/zinc sulfate
• calcium/magnesium/vitamin D/zinc
• calcium carbonate/magnesium oxide/zinc sulfate
• ascorbate/cobalamin/copper sulfate/ferrous fumarate/folic acid/manganese sulfate/nicotinamide/pantothenate/polysaccharide iron complex/pyridoxine/riboflavin/thiamine/zinc sulfate
• ascorbate/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese sulfate/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/zinc sulfate
• ascorbate/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese sulfate/nicotinamide/pantothenate/polysaccharide iron complex/pyridoxine/riboflavin/thiamine/zinc sulfate
• ascorbate/cobalamin/copper/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese/manganese sulfate/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/zinc sulfate
• ascorbate/cholecalciferol/cobalamin/copper sulfate/ferrous fumarate/folic acid/kelp/magnesium oxide/magnesium sulfate/nicotinamide/pyridoxine/riboflavin/vitamin a/zinc sulfate
• ascorbate/biotin/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese sulfate/nicotinic acid/pantothenate/polysaccharide iron complex/pyridoxine/riboflavin/thiamine/zinc sulfate
• alpha tocopheryl acetate/ascorbate/calcium carbonate/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium oxide/nicotinamide/potassium iodide/pyridoxine/retinol/riboflavin/thiamine/vitamin d/zinc sulfate
• acetaminophen/dextromethorphan/guaifenesin/zinc sulfate
• acetaminophen/dextromethorphan/doxylamine/zinc sulfate
• tetrahydrozoline/zinc sulfate
• chromic chloride/copper sulfate/manganese sulfate/zinc sulfate
• naphazoline/zinc sulfate

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=62640
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24424