zinc sulfate (ZnSO4, Zintrace)

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Indications

zinc supplement for zinc deficiency
may promote wound healing in patients with pressure ulcers
prophylaxis & treatment of the common cold
- zinc lozenges (within 24 hours of onset)
- supplementation for at least 5 months (prophylaxis)
acrodermatitis enteropathica^[5]

Dosage

RDA: 15 mg elemental Zn+2/day
zinc deficiency: 110-220 mg (25-50 mg elemental Zn+2) TID

Injection: 1 mg/mL (10 mL).

Pharmacokinetics

poor (20-30%) absorption from GI tract
elimination mostly in feces

Adverse effects

uncommon (< 1%)
- indigestion, nausea/vomiting, neutropenia, leukopenia, hypotension, jaundice, pulmonary edema

Drug interactions

tetracycline: decreased effect of tetracycline
iron, bran products, dairy products: reduced absorption of Zn+2

drug interaction(s) of diuretics in combination with Zn+2

Mechanism of action

cofactor for more than 70 enzymes

More general terms

zinc supplement

Additional terms

Zn+2

Component of

References

↑ Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
↑ Prescriber's Letter 11(3):17 2004
↑ Singh M and Das RR Zinc for the common cold The Cochrane Library http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD001364/frame.html
↑ ^5.0 ^5.1 Deprecated Reference

Database

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