mitochondrial antibody in body fluid

Indications

• primary biliary cirrhosis*

* primary biliary cirrhosis also known as primary biliary cholangitis

* laboratory values indicating need for anti-mitochondrial antibody

• elevated markers of cholangitis: increased serum ALP, serum GGT
• normal to near normal serum AST, serum ALT, serum bilirubin

Clinical significance

• autoantibody associated with primary biliary cirrhosis* directed at the mitochondrial M2 antigen
• high titers (1:160) are diagnostic of primary biliary cirrhosis*
  • antibodies preceed signs/symptoms
  • occur in adults NOT children, with rare exceptions
  • reacts with epitope in pyrvatate dehydrogenase-E2 containing lipoic acid
• lower titers associated with
  • chronic active hepatitis
  • alcoholic hepatitis
  • viral hepatitis

* primary biliary cirrhosis also known as primary biliary cholangitis

Specimen

• serum: store at -20 degrees C

More general terms

• serology

More specific terms

• mitochondrial antibody in CSF
• mitochondrial antibody in serum
• mitochondrial antibody qualitative
• mitochondrial antibody quantitative
• mitochondrial M2 antibody in body fluid

Additional terms

• anti-mitochondrial antibody
• primary biliary cirrhosis; primary biliary cholangitis