mitochondrial antibody in serum

Indications

• primary biliary cirrhosis*

* primary biliary cirrhosis also known as primary biliary cholangitis

* laboratory values indicating need for anti-mitochondrial antibody

• elevated markers of cholangitis: increased serum ALP, serum GGT
• normal to near normal serum AST, serum ALT, serum bilirubin

Clinical significance

• autoantibody associated with primary biliary cirrhosis directed at the mitochondrial M2 antigen
• high titers (1:160) are diagnostic of primary biliary cirrhosis
  • antibodies preceed signs/symptoms
  • occur in adults NOT children, with rare exceptions
  • reacts with epitope in pyrvatate dehydrogenase-E2 containing lipoic acid
• lower titers associated with
  • chronic active hepatitis
  • alcoholic hepatitis
  • viral hepatitis

Specimen

• serum: store at -20 degrees C

More general terms

• mitochondrial antibody in body fluid

More specific terms

• mitochondrial antibody in serum pattern
• mitochondrial antibody in serum qualitative
• mitochondrial antibody in serum quantitative
• mitochondrial IgG in serum
• mitochondrial M2 antibody in serum
• mitochondrial M4 antibody in serum
• mitochondrial M5 antibody in serum
• mitochondrial M9 antibody in serum

Additional terms

• primary biliary cirrhosis; primary biliary cholangitis