prediction of dementia
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Laboratory
- plasma proteomic profiles predict dementia 10 years in advance[1]
- plasma GFAP, NEFL, GDF15 & LTBP2 consistently associated with dementia
- people with higher plasma GFAP are 2.3 times more likely to develop dementia
- plasma GFAP identified as optimal marker for prediction of dementia
Diagnostic procedures
- higher machine learning-based EEG brain age index is associated with a higher risk of incident dementia[5]
Notes
- there is a dementia risk calculator based on clinical factors
- an MRI score is said to predict dementia[2]
- cardiovascular risk factors are said to predict dementia in CAIDE trial
- there is discussion of predicting dementia in primary care[3]
- artificial intelligence analyzed voice recordings may help predict which patients with mild cognitive impairment develop will Alzheimer's dementia within 6 years[4]
More general terms
References
- ↑ 1.0 1.1 Naddaf M Early dementia diagnosis: blood proteins reveal at-risk people. Nature News. 2024 Feb 12 PMID: https://pubmed.ncbi.nlm.nih.gov/38347211 https://www.nature.com/articles/d41586-024-00418-9
Guo Y, You J, Zhang Y et al Plasma proteomic profiles predict future dementia in healthy adults. Nature Aging. 2024. Feb 12. PMID: https://pubmed.ncbi.nlm.nih.gov/38347190 https://www.nature.com/articles/s43587-023-00565-0 - ↑ 2.0 2.1 Amin Al Olama A et al. Simple MRI score aids prediction of dementia in cerebral small vessel disease. Neurology 2020 Mar 24; 94:e1294. PMID: https://pubmed.ncbi.nlm.nih.gov/32123050 https://n.neurology.org/content/94/12/e1294
- ↑ 3.0 3.1 Jongstra S, van Gool WA, Moll van Charante EP et al Improving Prediction of Dementia in Primary Care. Ann Fam Med May/June 2018 vol. 16 no. 3 206-210 <PubMed> PMID: https://pubmed.ncbi.nlm.nih.gov/29760023 Free Article <Internet> http://www.annfammed.org/content/16/3/206
- ↑ 4.0 4.1 George J AI Helps Predict Dementia Using Speech Patterns. Voice recordings may spot who's likely to progress to Alzheimer's dementia in 6 years. MedPage Today June 26, 2024 https://www.medpagetoday.com/neurology/alzheimersdisease/110843
Amini S, Hao B, Yang J, Karjadi C, Kolachalama VB, Au R, Paschalidis IC. Prediction of Alzheimer's disease progression within 6 years using speech: A novel approach leveraging language models. Alzheimers Dement. 2024 Jun 25. PMID: https://pubmed.ncbi.nlm.nih.gov/38924662 https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13886 - ↑ 5.0 5.1 George J Brain Waves During Sleep Predict Dementia Risk. Microstructural EEG features may offer a scalable tool for early dementia detection. MedPage Today. March 23, 2026 https://www.medpagetoday.com/neurology/dementia/120450
Sun H, Milton S, Fang Y et al Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis. JAMA Netw Open. 2026 Mar 2;9(3):e261521. PMID: https://pubmed.ncbi.nlm.nih.gov/41854616 PMCID: PMC13003368 Free PMC article. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2846719